Chloride → [3-Methoxy-4-(4-methyl-imidazol-1-yl)-phenyl]-(8-phenyl-5,6,7,8-tetrahydro-pyrido[4,3-d]pyrimidin-2-yl)-amine hydrochloride

HRID 2076038노트

반응식

HRID 2076038 반응식
C(OC([N:8]1[CH2:32][CH:31]([C:33]2[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=2)[C:11]2[N:12]=[C:13]([NH:16][C:17]3[CH:22]=[CH:21][C:20]([N:23]4[CH:27]=[C:26]([CH3:28])[N:25]=[CH:24]4)=[C:19]([O:29][CH3:30])[CH:18]=3)[N:14]=[CH:15][C:10]=2[CH2:9]1)=O)(C)(C)C.[Cl-:39]>ClCCl.C(OCC)C>[ClH:39].[CH3:30][O:29][C:19]1[CH:18]=[C:17]([NH:16][C:13]2[N:14]=[CH:15][C:10]3[CH2:9][NH:8][CH2:32][CH:31]([C:33]4[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=4)[C:11]=3[N:12]=2)[CH:22]=[CH:21][C:20]=1[N:23]1[CH:27]=[C:26]([CH3:28])[N:25]=[CH:24]1

참가 물질

5

반응물 2

HCID 312ChlorideHCID 441941562-[3-methoxy-4-(4-methyl-imidazol-1-yl)-phenylamino]-8-phenyl-7,8-dihydro-5H-pyrido[4,3-d]pyrimidine-6-carboxylic acid tert.-butyl ester

생성물 1

HCID 44194157[3-Methoxy-4-(4-methyl-imidazol-1-yl)-phenyl]-(8-phenyl-5,6,7,8-tetrahydro-pyrido[4,3-d]pyrimidin-2-yl)-amine hydrochloride수율 100%

시약·촉매·용매 2

HCID 3283Diethyl Ether용매HCID 6344Dichloromethane용매

실험 절차

To a solution of 2-[3-methoxy-4-(4-methyl-imidazol-1-yl)-phenylamino]-8-phenyl-7,8-dihydro-5H-pyrido[4,3-d]pyrimidine-6-carboxylic acid tert.-butyl ester (75 mg, 0.15 mmol) in dichloromethane (1.5 mL) was added at 0° C. 2M hydrogene chloride (0.73 mL) in diethyl ether. The reaction was stirred at room temperature over night. The solvent was evaporated under reduced pressure to yield the title compound (70 mg, 100%) as a yellow solid. MS ISP (m/e): 413.4 (100) [(M+H)+]. 1H NMR (DMSO-D6, 300 MHz): δ (ppm)=10.01 (m, 2H), 9.23 (s, 1H), 8.57 (s, 1H), 7.71 (s, 1H), 7.59 (s, 1H), 7.26-7.38 (m, 6H), 7.15 (d, 1H), 4.56 (dd, 1H), 4.37 (m, 2H), 3.64 (m, 1H), 3.42 (m, 1H), 3.38 (s, 3H), 2.32 (s, 3H).

후처리

  1. customThe solvent was evaporated under reduced pressure

출처 및 근거

ORD 기록
ord-b9fe06ce9e744f31a31a703190f8d252
출처 데이터셋
uspto-grants-2011_04
특허 번호
US07923450B2

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