tert-Butoxy bis(dimethylamino)methane → 6-[1-Dimethylamino-methylidene]-2-(2,4-dichloro-phenyl)-cyclohexanone

반응식

[Cl:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[CH:9]1[CH2:14][CH2:13][CH2:12][CH2:11][C:10]1=[O:15].C(O[CH:21](N(C)C)[N:22]([CH3:24])[CH3:23])(C)(C)C>>[CH3:21][N:22]([CH3:24])[CH:23]=[C:11]1[C:10](=[O:15])[CH:9]([C:3]2[CH:4]=[CH:5][C:6]([Cl:8])=[CH:7][C:2]=2[Cl:1])[CH2:14][CH2:13][CH2:12]1

참가 물질

반응물 2

HCID 79885tert-Butoxy bis(dimethylamino)methane

HCID 184417612-(2,4-Dichlorophenyl)cyclohexan-1-one

생성물 1

HCID 670961116-[1-Dimethylamino-methylidene]-2-(2,4-dichloro-phenyl)-cyclohexanone

실험 절차

2-(2,4-dichloro-phenyl)-cyclohexanone (101 mg, 0.42 mmol) was reacted with tert.-butoxy-bis-(dimethylamino)-methane using in analogous manner the procedure described in example 45a) to give crude title compound (105 mg) as a red oil which was used directly in the next step. MS ISP (m/e): 298.3 [(M+H)+].

출처 및 근거

ORD 기록: ord-9be76db7ba004c96a6d8787a8d385ae2
출처 데이터셋: uspto-grants-2011_04
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07923450B2

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