Triphenylphosphine → 3-(1,3-Dioxo-1,3-dihydro-isoindol-2-yloxy)-2,2-dimethyl-propionic acid methyl ester

https://huagongshe.com/reaction/20761

참여 물질

역할	이름	HCID	투입량
반응물	Triphenylphosphine	HCID 11776	—
반응물	Diisopropyl diazene-1,2-dicarboxylate	HCID 75555	—
반응물	Methyl 3-hydroxypivalate	HCID 84152	—
반응물	4-hydroxy-2,3-dihydro-1H-isoindole-1,3-dione	HCID 346002	—
용매	Tetrahydrofuran	HCID 8028	—
생성물	3-(1,3-Dioxo-1,3-dihydro-isoindol-2-yloxy)-2,2-dimethyl-propionic acid methyl ester	HCID 59348026	33.6%

반응 조건

온도	0 °C

반응 단계

To methyl hydroxypivalate (1.31 g, 9.89 mmol) were added tetrahydrofuran (40 ml), hydroxyphthalimide (3.23 g, 19.78 mmol) and triphenylphosphine (6.48 g, 24.73 mmol). After this solution was cooled to 0° C., diisopropyl azodicarboxylate (4.87 ml, 24.73 mmol) was added dropwise to the solution. While being allowed to warm gradually, the reaction mixture was stirred for 12 hours, and concentrated under reduced pressure. The residue was roughly purified by silica gel column chromatography to give the title compound (922 mg).

출처 및 근거

DOI	10.6084/m9.figshare.5104873.v1
특허 번호	US07745663B2
출처 데이터셋	uspto-grants-2010_06
ORD ID	ord-97c9716f95c14692a5ef32b3dbd750ba
출처 메모	uspto-grants-2010_06