Methylamine → 3-aminooxy-2,2,N-trimethyl-propionamide

HRID 20762노트

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HRID 20762 반응식
C[O:2][C:3](=O)[C:4]([CH3:19])([CH3:18])[CH2:5][O:6][N:7]1C(=O)C2C(=CC=CC=2)C1=O.[CH3:21][NH2:22]>CO>[NH2:7][O:6][CH2:5][C:4]([CH3:19])([CH3:18])[C:3]([NH:22][CH3:21])=[O:2]

참가 물질

4

반응물 2

HCID 6329MethylamineHCID 593480263-(1,3-Dioxo-1,3-dihydro-isoindol-2-yloxy)-2,2-dimethyl-propionic acid methyl ester

생성물 1

HCID 553004123-aminooxy-2,2,N-trimethyl-propionamide

시약·촉매·용매 1

HCID 887Methanol용매

반응 조건

온도
60 °C

실험 절차

To 3-(1,3-dioxo-1,3-dihydro-isoindol-2-yloxy)-2,2-dimethyl-propionic acid methyl ester (800 mg) obtained in Step A was added a 40% solution of methylamine in methanol (6 ml), and the mixture was stirred at 60° C. for 13 hours. After the reaction mixture was concentrated under reduced pressure, dichloromethane was added to the residue, and insoluble matter was filtered. The filtrate was concentrated, and the residue was purified by silica gel column chromatography to give the title compound (202 mg).

후처리

  1. concentrationAfter the reaction mixture was concentrated under reduced pressure, dichloromethane
  2. additionwas added to the residue, and insoluble matter
  3. filtrationwas filtered
  4. concentrationThe filtrate was concentrated
  5. customthe residue was purified by silica gel column chromatography

출처 및 근거

ORD 기록
ord-d43277e76df54f6e872b18dd2e300859
출처 데이터셋
uspto-grants-2010_06
특허 번호
US07745663B2

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