Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Diethyl Oxalate → Ethyl 2-oxo-2-(10-oxotricyclo[6.2.2.02,7]dodeca-2,4,6-trien-9-yl)acetate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Diethyl Oxalate | HCID 7268 | — |
| 반응물 | Hexamethyldisilazane | HCID 13838 | — |
| 반응물 | 1,4-Ethanonaphthalen-2(1H)-one, 3,4-dihydro- | HCID 582596 | — |
| 반응물 | 10-(2,4-Dichlorophenyl)-10,11-diazatetracyclo[6.5.2.02,7.09,13]pentadeca-2,4,6,9(13),11-pentaene-12-carboxylic acid | HCID 86623337 | — |
| 반응물 | Butyllithium | HCID 178418339 | — |
| 생성물 | Ethyl 2-oxo-2-(10-oxotricyclo[6.2.2.02,7]dodeca-2,4,6-trien-9-yl)acetate | HCID 67029310 | — |
반응 단계
The title product was prepared by a procedure similar to that described for step 1 of intermediate 1. From tricyclo[6.2.2.02,7]dodeca-2,4,6-trien-9-one [prepared by one of the methods available in the art of organic synthesis, e.g., as described in Hales et. al. Tetrahedron, 1995, 51, 7777-7790] (2.5 g, 14.53 mmol), hexamethyldisilazane (4.9 ml, 23.2 mmol), 2.34M n-BuLi (10 ml, 23.4 mmol) and diethyl oxalate (3.18 ml, 21.18 mmol) the desired product was obtained (2.3 g, 63%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07923465B2 |
| 출처 데이터셋 | uspto-grants-2011_04 |
| ORD ID | ord-aead04f9196a4ba889d38cebd8cb4036 |
| 출처 메모 | uspto-grants-2011_04 |