2-Chloro-5-nitroquinoline → Rac-1-methyl-1h-indole-4-sulfonic acid [2-(7-methoxy-indan-1-ylamino)-quinolin-5-yl]-amide

HRID 2076314

반응식

HRID 2076314 반응식
[N+:1]([C:4]1[CH:13]=[CH:12][CH:11]=[C:10]2[C:5]=1[CH:6]=[CH:7][C:8](Cl)=[N:9]2)([O-])=O.[CH3:15][O:16][C:17]1[CH:18]=[CH:19][CH:20]=[C:21]2[C:25]=1[CH:24]([NH2:26])[CH2:23][CH2:22]2.[CH3:27][N:28]1[C:36]2[CH:35]=[CH:34][CH:33]=[C:32]([S:37](Cl)(=[O:39])=[O:38])[C:31]=2[CH:30]=[CH:29]1>>[CH3:15][O:16][C:17]1[CH:18]=[CH:19][CH:20]=[C:21]2[C:25]=1[CH:24]([NH:26][C:8]1[CH:7]=[CH:6][C:5]3[C:10](=[CH:11][CH:12]=[CH:13][C:4]=3[NH:1][S:37]([C:32]3[C:31]4[CH:30]=[CH:29][N:28]([CH3:27])[C:36]=4[CH:35]=[CH:34][CH:33]=3)(=[O:38])=[O:39])[N:9]=1)[CH2:23][CH2:22]2

참가 물질

4

반응물 3

HCID 3192512-Chloro-5-nitroquinolineHCID 185257821-methyl-1H-indole-4-sulfonyl chlorideHCID 186198817-Methoxy-2,3-dihydro-1H-inden-1-amine

생성물 1

HCID 25019328Rac-1-methyl-1h-indole-4-sulfonic acid [2-(7-methoxy-indan-1-ylamino)-quinolin-5-yl]-amide

실험 절차

The title compound, MS: m/e=499.0 (M+H+), was prepared in accordance with the general method of example 45 from 5-nitro-2-chloroquinoline, rac-7-methoxy-indane-1-ylamine and 1-methyl-1H-indole-4-sulfonylchloride.

출처 및 근거

ORD 기록
ord-84b80179b4484f7788a30fdee1fca68f
출처 데이터셋
uspto-grants-2011_04
특허 번호
US07923561B2

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