Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
4-Amino-5-pyrimidinecarboxamide → HCID 135923523, 화합물
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 4-Amino-5-pyrimidinecarboxamide | HCID 818212 | — |
| 반응물 | Lithium Hexamethyldisilazide | HCID 2733832 | — |
| 반응물 | (2-m-Tolyl-ethoxy)-acetic acid methyl ester | HCID 67099145 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | HCID 135923523 | HCID 135923523 | — |
반응 단계
In analogy to example 3.3, 4-amino-5-pyrimidinecarboxamide and (2-m-tolyl-ethoxy)-acetic acid methyl ester (prepared from 2-m-tolyl-ethanol [1875-89-4] in analogy to example 3.1-3.2) reacted in the presence of LiHMDS in THF to yield the title compound (after purification of the crude product with column chromatography (silica gel, EtOAc/MeOH) and crystallization from TBME) as white solid. MS: m/e=295.5 [M−H−].
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07928106B2 |
| 출처 데이터셋 | uspto-grants-2011_04 |
| ORD ID | ord-ca34c62bdfdf40b38c1e7d6eb9faadd6 |
| 출처 메모 | uspto-grants-2011_04 |