Ethylamine → N-ethyl-4-methoxybenzenesulfonamide

HRID 2077510노트

반응식

HRID 2077510 반응식
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([S:9](Cl)(=[O:11])=[O:10])=[CH:5][CH:4]=1.[CH2:13]([NH2:15])[CH3:14]>C(Cl)Cl>[CH2:13]([NH:15][S:9]([C:6]1[CH:7]=[CH:8][C:3]([O:2][CH3:1])=[CH:4][CH:5]=1)(=[O:11])=[O:10])[CH3:14]

참가 물질

4

반응물 2

HCID 6341EthylamineHCID 74014-Methoxybenzenesulfonyl chloride

생성물 1

HCID 4453230N-ethyl-4-methoxybenzenesulfonamide수율 112%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

4-Methoxybenzene-1-sulfonyl chloride (619.5 mg, 2.999 mmol) was dissolved in DCM (10 mL) and ethylamine (4.6 mL, 2.0 M in THF, 9.2 mmol) was added, and the reaction flask was put in a water bath and stirred under nitrogen. After stirring at RT over the weekend, the suspension was filtered, and the solid was washed with DCM. The filtrate was concentrated and dried under high vacuum to provide N-ethyl-4-methoxybenzenesulfonamide (723 mg, 89% yield). MS (ESI pos. ion) m/z: 216 (MH+). Calculated exact mass for C9H13NO3S: 215.

후처리

  1. customthe reaction flask was put in a water bath
  2. stirringAfter stirring at RT over the weekend
  3. filtrationthe suspension was filtered
  4. washthe solid was washed with DCM
  5. concentrationThe filtrate was concentrated
  6. customdried under high vacuum

출처 및 근거

ORD 기록
ord-5cbd9edec7f444d98af3a89e42fafd73
출처 데이터셋
uspto-grants-2011_04
특허 번호
US07928140B2

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