Water → N-(5-Bromothiazolo[5,4-b]pyridin-2-yl)acetamide

HRID 2077539

반응식

HRID 2077539 반응식
Br[C:2]1[C:7]([NH2:8])=[CH:6][CH:5]=[C:4]([Br:9])[N:3]=1.[C:10]([N:13]=[C:14]=[S:15])(=[O:12])[CH3:11].O>CC(C)=O>[Br:9][C:4]1[N:3]=[C:2]2[S:15][C:14]([NH:13][C:10](=[O:12])[CH3:11])=[N:8][C:7]2=[CH:6][CH:5]=1

참가 물질

5

반응물 3

HCID 962WaterHCID 128851Acetyl isothiocyanateHCID 8176783-Amino-2,6-dibromopyridine

생성물 1

HCID 56763853N-(5-Bromothiazolo[5,4-b]pyridin-2-yl)acetamide수율 121.2%

시약·촉매·용매 1

HCID 180Acetone용매

반응 조건

온도
67.5 °C

실험 절차

2,6-dibromopyridin-3-amine (4.235 g, 16.8 mmol) was dissolved in acetone and acetyl isothiocyanate (1.85 ml, 21.0 mmol) was added. The flask was fit with a reflux condensor and placed in a preheated oil bath (65-70° C.) and stirred under nitrogen for 2.5 hours. Then, the reaction was cooled to room temperature, poured into water, and filtered. The solid was washed with water, saturated sodium bicarbonate, and water again, and then collected and dried under high vacuum to afford N-(5-bromothiazolo[5,4-b]pyridin-2-yl)acetamide (5.54 g, Yield >100%).

후처리

  1. customplaced in a preheated oil bath
  2. temperatureThen, the reaction was cooled to room temperature
  3. filtrationfiltered
  4. washThe solid was washed with water, saturated sodium bicarbonate, and water again
  5. customcollected
  6. customdried under high vacuum

출처 및 근거

ORD 기록
ord-b5afa79e6b4742d984f01cd24eb5d381
출처 데이터셋
uspto-grants-2011_04
특허 번호
US07928140B2

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