Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Cyclohexanecarboxylic acid → N-(6-bromobenzo[d]thiazol-2-yl)cyclohexanecarboxamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Cyclohexanecarboxylic acid | HCID 7413 | — |
| 반응물 | Diisopropylethylamine | HCID 81531 | — |
| 반응물 | 2-Benzothiazolamine, 6-bromo- | HCID 85149 | — |
| 반응물 | Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 9886157 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | N-(6-bromobenzo[d]thiazol-2-yl)cyclohexanecarboxamide | HCID 4604615 | 78.4% |
반응 단계
A mixture of Hunig's base (286 μl, 1637 μmol), HATU (830 mg, 2182 μmol) and cyclohexanecarboxylic acid (147 mg, 1146 μmol) was dissolved in 2.0 mL CH2Cl2 and stirred at room temperature for 10 min. 6-bromobenzo[d]thiazol-2-amine (250 mg, 1091 μmol) was added, and stirring was continued overnight. The solids were filtered and washed with CH2Cl2. The filtrate was concentrated, dissolved in CH2Cl2 and purified by silica gel chromatography using 100% CH2Cl2 to provide N-(6-bromobenzo[d]thiazol-2-yl)cyclohexanecarboxamide (290 mg, 78% yield) as a white solid. MS (ESI pos. ion) m/z calc'd for C14H15BrN2OS: 339.3/341.3. found 339.0/341.0.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07928140B2 |
| 출처 데이터셋 | uspto-grants-2011_04 |
| ORD ID | ord-9ed56c1abbf44a52bf197a3bc1952a2c |
| 출처 메모 | uspto-grants-2011_04 |