Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Phenol → 4-(4-(N-methylsulfamoyl)phenoxy)benzene
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Phenol | HCID 996 | — |
| 반응물 | 4-bromo-N-methylbenzene-1-sulfonamide | HCID 101215 | — |
| 생성물 | 4-(4-(N-methylsulfamoyl)phenoxy)benzene | HCID 23614577 | — |
반응 단계
Entry 54: 4-Bromobenzenesulfonyl chloride was reacted with methylamine according to Method A15, Step 1 to afford N-methyl-4-bromobenzenesulfonamide. N-Methyl-4-bromobenzenesulfonamide was coupled with phenol according to Method 15, Step 2 to afford 4-(4-(N-methylsulfamoyl)phenoxy)benzene. 4-(4-(N-Methylsulfamoyl)phenoxy)benzene was converted into 4-(4-(N-methylsulfamoyl)phenoxy)-1-nitrobenzene according to Method A15, Step 3. 4-(4-(N-Methylsulfamoyl)phenoxy)-1-nitrobenzene was reduced to 4-(4-N-methylsulfamoyl)phenyloxy)aniline according to Method A15, Step 4. According to Method C1a, 4-chloro-3-(trifluoromethyl)phenyl isocyanate was reacted with 4-(3-N-methylsulfamoyl)phenyloxy)aniline to afford the urea.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07928239B2 |
| 출처 데이터셋 | uspto-grants-2011_04 |
| ORD ID | ord-ebd0c5f42a6f46e6a637d9edc3b744c0 |
| 출처 메모 | uspto-grants-2011_04 |