Thionyl Chloride → 2-Benzyloxy-ethanesulfonyl chloride
반응식
[CH2:1]([O:8][CH2:9][CH2:10][S:11]([OH:14])(=O)=[O:12])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.S(Cl)([Cl:17])=O>CN(C)C=O>[CH2:1]([O:8][CH2:9][CH2:10][S:11]([Cl:17])(=[O:14])=[O:12])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1참가 물질
4
실험 절차
To a 2-(benzyloxy)ethanesulfonic acid (4.0 g) was added thionyl chloride (13.5 ml) dropwise at ambient temperature for 15 minutes and the mixture was stirred at the same temperature for 10 minutes. To the mixture was added dropwise N,N-dimethylformamide (0.072 ml) at ambient temperature. The mixture was stirred at the same temperature for 20 minutes and refluxed for 1 hour. After cooling down to room temperature, the mixture was evaporated under reduced pressure to give 2-(benzyloxy)ethanesulfonyl chloride (4.1 g).
후처리
- stirringThe mixture was stirred at the same temperature for 20 minutes
- temperaturerefluxed for 1 hour
- customthe mixture was evaporated under reduced pressure
출처 및 근거
- ORD 기록
- ord-8da05fb1ee3346c88a79edd938e9d889
- 출처 데이터셋
- uspto-grants-2011_04
- 특허 번호
- US07928264B2
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