5-Methylthiophene-2-carboxylic acid → 1-(5-Phenyl-thieno[3,2-c]pyrazol-1-yl)-ethanone

반응식

CO[C:3]([C:5]1[S:12][C:11]2[CH:10]=[N:9][N:8]([C:13](=[O:15])[CH3:14])[C:7]=2[CH:6]=1)=O.[CH3:16][C:17]1S[C:20](C(O)=O)=[CH:19][CH:18]=1>>[C:3]1([C:5]2[S:12][C:11]3[CH:10]=[N:9][N:8]([C:13](=[O:15])[CH3:14])[C:7]=3[CH:6]=2)[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1

참가 물질

반응물 2

HCID 747135-Methylthiophene-2-carboxylic acid

HCID 57637373Methyl 1-acetyl-1H-thieno[3,2-c]pyrazole-5-carboxylate

생성물 1

HCID 576373781-(5-Phenyl-thieno[3,2-c]pyrazol-1-yl)-ethanone

실험 절차

1-(5-phenyl-thieno[3,2-c]pyrazol-1-yl)-ethanone [Intermediate (44), LC/MS: 243.1 (M+H), RT=3.45 minutes; 1H NMR (300 Mhz, CDCl3): δ 7.84 (s, 1H), 7.78 (s, 1H), 7.64 (m, 2H), 7.43-7.31 (m, 3H), 2.75 (s, 3H)] is prepared using procedures similar to those described hereinabove for Intermediate (25) substituting 2-phenyl-5-methyl-thiophene for 5-methylthiophene-2-carboxylic acid in step 1.

출처 및 근거

ORD 기록: ord-0d8f2615a58a427ba20b8b65288f8103
출처 데이터셋: uspto-grants-2011_04
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07928231B2

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