4-Morpholinopiperidine → N-(2,4-difluorophenyl)-N-methyl-8-(4-morpholinopiperidine-1-yl)-4H-thieno[3,2-c]chromene-2-carboxamide

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Following Example 70 and General Procedure D, 8-bromo-N-(2,4-difluorophenyl)-N-methyl-4H-thieno[3,2-c]chromene-2-carboxamide 160bp and 4-(4-piperidinyl)morpholine were reacted to give 127bp. 1H NMR (400 MHz, CDCl3) δ 7.20 (m, 1H), 7.05-7.10 (m, 2H), 6.84-6.93 (m, 3H), 6.74 (m, 1H), 5.05 (s, 2H), 4.00 (m, 4H), 3.63-3.68 (m, 3H), 3.29-3.50 (m, 5H), 3.18 (m, 2H), 3.05 (m, 2H), 2.47 (m, 2H), 2.21 (m, 2H). LCMS (ESI) m/z: 526.1

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