Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Sodium borohydride → (+/-)1-[1-(1-Azetidinyl)cyclopentyl]-1-phenylmethanamine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Sodium borohydride | HCID 4311764 | — |
| 반응물 | {1-[Amino(phenyl)methyl]cyclopentyl}dimethylamine | HCID 11521393 | — |
| 반응물 | 1-(1-Azetidinyl)cyclopentanecarbonitrile | HCID 59347779 | — |
| 반응물 | HCID 178506676 | HCID 178506676 | — |
| 용매 | Methanol | HCID 887 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | (+/-)1-[1-(1-Azetidinyl)cyclopentyl]-1-phenylmethanamine | HCID 59347827 | 47% |
반응 단계
The title compound (0.45 g, 47%) was prepared from 1-(1-azetidinyl)cyclopentanecarbonitrile D13 (0.60 g, 4.0 mmol), and phenyllithium in ethers (2.6 ml of a 1.7M solution; 4.4 mmol) in THF (5 ml), followed by reaction with sodium borohydride (0.456 g, 12 mmol) in methanol (5 ml) in a similar manner to that described in D2. 1H NMR (CDCl3) δ: 0.67 (1H, m), 1.06 (1H, m), 1.32 (4H, m), 1.48 (2H, m), 1.91-2.03 (4H, m), 3.24 (4H, m), 3.83 (1H, s), 7.20-7.32 (3H, m), 7.44 (2H, m).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07745642B2 |
| 출처 데이터셋 | uspto-grants-2010_06 |
| ORD ID | ord-4a1f6424cb75411fb3b7839e04221e0e |
| 출처 메모 | uspto-grants-2010_06 |