Ethyl Acetate → 2-(3-(4-bromo-2-(trifluoromethyl)phenoxy)propoxy)tetrahydro-2H-pyran

HRID 2079528노트

반응식

HRID 2079528 반응식
[Br:1][C:2]1[CH:12]=[CH:11][C:5]([O:6][CH2:7][CH2:8][CH2:9][OH:10])=[C:4]([C:13]([F:16])([F:15])[F:14])[CH:3]=1.O.[C:18]1(C)C=[CH:22][C:21](S(O)(=O)=O)=[CH:20][CH:19]=1.C(OCC)(=[O:31])C>C1COCC1.C(=O)([O-])[O-].[Na+].[Na+]>[Br:1][C:2]1[CH:12]=[CH:11][C:5]([O:6][CH2:7][CH2:8][CH2:9][O:10][CH:22]2[CH2:21][CH2:20][CH2:19][CH2:18][O:31]2)=[C:4]([C:13]([F:14])([F:15])[F:16])[CH:3]=1

참가 물질

6

반응물 3

HCID 8857Ethyl AcetateHCID 521998p-Toluenesulfonic acid monohydrateHCID 576575913-(4-Bromo-2-(trifluoromethyl)-phenoxy)propan-1-ol

생성물 1

HCID 576575642-(3-(4-bromo-2-(trifluoromethyl)phenoxy)propoxy)tetrahydro-2H-pyran

시약·촉매·용매 2

HCID 8028Tetrahydrofuran용매HCID 10340Sodium Carbonate용매

실험 절차

A mixture of 3-(4-bromo-2-(trifluoromethyl)-phenoxy)propan-1-ol (12 g), 3,4-dihydro-2H-puran (6.75 g) and p-toluenesulfonic acid hydrate (0.76 g) in THF (100 ml) was stirred at room temperature for 1 hour then diluted with 10% sodium carbonate (50 ml) and extrated with ethyl acetate (2×150 ml). Organic layer was then dried over sodium sulphate, solvent removed under reduced pressure to give expected product (15 g).

후처리

  1. dry with materialOrganic layer was then dried over sodium sulphate, solvent
  2. customremoved under reduced pressure

출처 및 근거

ORD 기록
ord-265484f509b847db9ab02dee04ada42b
출처 데이터셋
uspto-grants-2011_04
특허 번호
US07932251B2

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