1,2-Dichloro-4-nitrobenzene → 8-(2-Chloro-4-nitrophenyl)-1,4-dioxa-8-azaspiro[4.5]decane

반응식

[Cl:1][C:2]1[CH:3]=[C:4]([N+:9]([O-:11])=[O:10])[CH:5]=[CH:6][C:7]=1Cl.[O:12]1[C:16]2([CH2:21][CH2:20][NH:19][CH2:18][CH2:17]2)[O:15][CH2:14][CH2:13]1>>[Cl:1][C:2]1[CH:3]=[C:4]([N+:9]([O-:11])=[O:10])[CH:5]=[CH:6][C:7]=1[N:19]1[CH2:20][CH2:21][C:16]2([O:15][CH2:14][CH2:13][O:12]2)[CH2:17][CH2:18]1

참가 물질

반응물 2

HCID 74431,2-Dichloro-4-nitrobenzene

HCID 674351,4-Dioxa-8-azaspiro(4.5)decane

생성물 1

HCID 354167758-(2-Chloro-4-nitrophenyl)-1,4-dioxa-8-azaspiro[4.5]decane

실험 절차

The title compound 3.05 g (quantitative) was obtained in a manner similar to the Manufacturing Example 25 by use of 3,4-dichloronitrobenzene and 1,4-dioxa-8-azaspiro[4.5]decane, instead of 3,4-difluoronitorobenzene and N-methylpiperazine, respectively.

출처 및 근거

ORD 기록: ord-5fbe1b4302d74b238fd6a819d83c6585
출처 데이터셋: uspto-grants-2011_04
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07932250B2

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