Urea → HCID 178517453, 화합물

HRID 2079624

반응식

HRID 2079624 반응식
[NH2:1][C:2]1[C:7](F)=[CH:6][C:5](Br)=[CH:4][C:3]=1[CH2:10]O.[NH2:12][C:13](N)=[O:14]>O>[OH:14][C:13]1[N:12]=[CH:10][C:3]2[C:2](=[CH:7][CH:6]=[CH:5][CH:4]=2)[N:1]=1

참가 물질

4

반응물 2

HCID 1176UreaHCID 54312525(2-Amino-5-bromo-3-fluorophenyl)methanol

생성물 1

HCID 178517453HCID 178517453, 화합물

시약·촉매·용매 1

HCID 962Water용매

반응 조건

온도
175 °C

실험 절차

A mixture of (2-amino-5-bromo-3-fluorophenyl)methanol (5.6 g, 23.7 mmol, obtained from step 3) and urea (21 g, 15 equiv.) was heated to 175° C. with vigorous stirring for 15 min. The reaction was cooled to room temperature and water was added. The solid was collected by filtration. Air-dried to give 2-hydroxyquinazoline as a light brown solid.

후처리

  1. temperatureThe reaction was cooled to room temperature
  2. filtrationThe solid was collected by filtration
  3. customAir-dried

출처 및 근거

ORD 기록
ord-486e6bc52795484eb35f0ae084caf42b
출처 데이터셋
uspto-grants-2011_04
특허 번호
US07932262B2

연결된 노트

불러오는 중…