Urea → HCID 178517453, 화합물

HRID 2079626

반응식

HRID 2079626 반응식
[NH2:1][C:2]1[C:7](Cl)=[CH:6][C:5](Br)=[CH:4][C:3]=1[CH2:10]O.[NH2:12][C:13](N)=[O:14]>O>[OH:14][C:13]1[N:12]=[CH:10][C:3]2[C:2](=[CH:7][CH:6]=[CH:5][CH:4]=2)[N:1]=1

참가 물질

4

반응물 2

HCID 1176UreaHCID 67080684(2-Amino-5-bromo-3-chlorophenyl)methanol

생성물 1

HCID 178517453HCID 178517453, 화합물

시약·촉매·용매 1

HCID 962Water용매

반응 조건

온도
180 °C

실험 절차

A mixture of (2-amino-5-bromo-3-chlorophenyl)methanol (3.3 g, obtained from step 3) and urea (10.5 g, 15 equiv.) was heated to 180° C. with vigorous stirring for 1 hr. The reaction was cooled to room temperature and water was added. The solid was collected by filtration. Air-dried to give 2-hydroxyquinazoline as a yellow powder (2.18 g, crude). ES/MS m/z 259/261 (MH+).

후처리

  1. temperatureThe reaction was cooled to room temperature
  2. filtrationThe solid was collected by filtration
  3. customAir-dried

출처 및 근거

ORD 기록
ord-aa91e9504bab4eaa9adb9c8601ef4982
출처 데이터셋
uspto-grants-2011_04
특허 번호
US07932262B2

연결된 노트

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