Sulfanilamide → 4-[[8-Bromo-6-(trifluoromethyl)-2-quinazolinyl]amino]benzenesulfonamide

HRID 2079629노트

반응식

HRID 2079629 반응식
[Br:1][C:2]1[CH:3]=[C:4]([C:13]([F:16])([F:15])[F:14])[CH:5]=[C:6]2[C:11]=1[N:10]=[C:9](Cl)[N:8]=[CH:7]2.[S:17]([NH2:27])(=[O:26])([C:19]1[CH:24]=[CH:23][C:22]([NH2:25])=[CH:21][CH:20]=1)=[O:18]>CC(O)C>[Br:1][C:2]1[CH:3]=[C:4]([C:13]([F:16])([F:15])[F:14])[CH:5]=[C:6]2[C:11]=1[N:10]=[C:9]([NH:25][C:22]1[CH:23]=[CH:24][C:19]([S:17]([NH2:27])(=[O:18])=[O:26])=[CH:20][CH:21]=1)[N:8]=[CH:7]2

참가 물질

4

반응물 2

HCID 5333SulfanilamideHCID 59199251HCID 59199251, 화합물

생성물 1

HCID 250160044-[[8-Bromo-6-(trifluoromethyl)-2-quinazolinyl]amino]benzenesulfonamide

시약·촉매·용매 1

HCID 3776Isopropanol용매

반응 조건

온도
110 °C

실험 절차

To a 0.30 M solution of 8-bromo-2-chloro-6-(trifluoromethyl)quinazoline in 2-propanol was added sulfanilamide (1.0 eq). The reaction was stirred at 110° C. for 14 h. The hydrochloride was collected by vacuum filtration and then stirred in aqueous sodium bicarbonate. The solid was collected by vacuum filtration and rinsed with water. The light yellow solid was dried in a desiccator to give 343 mg of the desired product. ES/MS m/z 447, 449 (MH+).

후처리

  1. filtrationThe hydrochloride was collected by vacuum filtration
  2. stirringstirred in aqueous sodium bicarbonate
  3. filtrationThe solid was collected by vacuum filtration
  4. washrinsed with water
  5. customThe light yellow solid was dried in a desiccator

출처 및 근거

ORD 기록
ord-0ded3928daca4d30a4e71ee1571a8a08
출처 데이터셋
uspto-grants-2011_04
특허 번호
US07932262B2

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