Acetic Acid → HCID 178488670, 화합물

HRID 2079659노트

반응식

HRID 2079659 반응식
C[CH2:2][C:3]([C:5]1[CH:10]=[CH:9][C:8]([O:11][CH3:12])=[CH:7][C:6]=1[NH2:13])=O.[NH2:14][C:15](N)=[O:16].[C:18](O)(=O)C>O>[CH3:18][C:10]1[CH:9]=[C:8]([O:11][CH3:12])[CH:7]=[C:6]2[C:5]=1[C:3]([CH3:2])=[N:14][C:15]([OH:16])=[N:13]2

참가 물질

5

반응물 3

HCID 176Acetic AcidHCID 1176UreaHCID 10442276HCID 10442276, 화합물

생성물 1

HCID 178488670HCID 178488670, 화합물

시약·촉매·용매 1

HCID 962Water용매

반응 조건

온도
100 °C

실험 절차

To methyl 1-(4-methoxy-2-aminophenyl)ethanone (1 eq) was added urea (5 eq) and few mls of acetic acid the mixture was heated to 100° C. for 16 h. To the crude was added water and the precipitated solid was filtered to give methyl 7-methoxy-4-methylquinazolin-2-ol in quantitative yield. ES/MS m/z 191 (MH+).

후처리

  1. filtrationthe precipitated solid was filtered

출처 및 근거

ORD 기록
ord-a9a2c0b2c0f94704be3af348d82d9abc
출처 데이터셋
uspto-grants-2011_04
특허 번호
US07932262B2

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