Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Potassium Carbonate → 2-Fluoro-4-(6-nitro-1H-indol-3-yl)-benzonitrile
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | (4-Cyano-3-fluorophenyl)boronic acid | HCID 2783130 | — |
| 반응물 | 1-benzenesulfonyl-3-bromo-6-nitro-1H-indole | HCID 57442196 | — |
| 반응물 | 4-(1-Benzenesulfonyl-6-nitro-1H-indol-3-yl)-2-fluoro-benzonitrile | HCID 67101102 | — |
| 촉매 | Bis(dibenzylideneacetone)palladium | HCID 9811564 | — |
| 용매 | Water | HCID 962 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | 2-Fluoro-4-(6-nitro-1H-indol-3-yl)-benzonitrile | HCID 57442195 | — |
반응 단계
4-(1-Benzenesulfonyl-6-nitro-1H-indol-3-yl)-2-fluoro-benzonitrile from 1-benzenesulfonyl-3-bromo-6-nitro-1H-indole, 7, and 3-fluoro-4-cyanophenylboronic acid using Method AA: Pd2(dba)3, [(t-Bu3)PH]BF4, K2CO3, THF, H2O. Purify by precipitation from EtOAc/hexanes. Remove the benzenesulfonyl protecting group using TBAF and THF as described for 4-(6-nitro-1H-indol-3-yl)-benzonitrile (9) below. LRMS (API ES−)=280.0 (M−1).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07932284B2 |
| 출처 데이터셋 | uspto-grants-2011_04 |
| ORD ID | ord-c55f1a02ecc442089933a62b63cec9f9 |
| 출처 메모 | uspto-grants-2011_04 |