Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
4-(1-isopropyl-6-nitro-1H-indol-3-yl)-benzonitrile → 4-(6-amino-1-isopropyl-1H-indol-3-yl)-benzonitrile
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 4-(1-isopropyl-6-nitro-1H-indol-3-yl)-benzonitrile | HCID 57442194 | — |
| 반응물 | HCID 178418361 | HCID 178418361 | — |
| 촉매 | Platinum oxide (PtO) | HCID 82844 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | 4-(6-amino-1-isopropyl-1H-indol-3-yl)-benzonitrile | HCID 57442201 | 99.7% |
반응 단계
Method E Placc 4-(1-isopropyl-6-nitro-1H-indol-3-yl)-benzonitrile (4, R1=i-Pr, R3=4-benzonitrile) 250 mg, 0.82 mmol) in a 50 mL flask and add a suspension of platinum (II) oxide (16 mg) in tetrahydrofuran (9 mL). Place the reaction under 1 atmosphere of hydrogen and stir until the starting material is consumed. Filter through a celite pad and wash the pad with ethyl acetate (50 mL). Concentrate the combined filtrates to give 225.0 mg of the title compound (99%). LRMS (API ES+)=276.0 (M+H).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07932284B2 |
| 출처 데이터셋 | uspto-grants-2011_04 |
| ORD ID | ord-91566e7c6935422598c04403973d2157 |
| 출처 메모 | uspto-grants-2011_04 |