Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Riboflavin → 5-(6-amino-1-isopropyl-1H-indol-3-yl)-pyridine-2-carbonitrile
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Riboflavin | HCID 493570 | — |
| 반응물 | 4-(1-isopropyl-6-nitro-1H-indol-3-yl)-benzonitrile | HCID 57442194 | — |
| 반응물 | 4-(6-amino-1-isopropyl-1H-indol-3-yl)-benzonitrile | HCID 57442201 | — |
| 촉매 | Palladium | HCID 23938 | — |
| 촉매 | Platinum oxide (PtO) | HCID 82844 | — |
| 생성물 | 5-(6-amino-1-isopropyl-1H-indol-3-yl)-pyridine-2-carbonitrile | HCID 67101189 | — |
반응 단계
Method F This compound can be prepared from 5-(1-isopropyl-6-nitro-1H-indol-3-yl)-pyridine-2-carbonitrile (4, R1=i-Pr, R3=5-(2-cyanopyridine)) in a manner substantially similar to that described immediately above for 4-(6-amino-1-isopropyl-1H-indol-3-yl)-benzonitrile except Degussa type E101 NE/W 10% Palladium on activated carbon can be used instead of platinum (II) oxide in Method E. LRMS (API ES+)=277.0 (M+H).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07932284B2 |
| 출처 데이터셋 | uspto-grants-2011_04 |
| ORD ID | ord-06449a27ab5444758edff0c311d6740c |
| 출처 메모 | uspto-grants-2011_04 |