Acrylonitrile → 4-Cyano-2-diaminomethylene-butyric acid ethyl ester

HRID 2079945노트

반응식

HRID 2079945 반응식
Cl.[CH2:2]([O:4][C:5](=[O:10])[CH:6]=[C:7]([NH2:9])[NH2:8])[CH3:3].C(N(CC)CC)C.[C:18](#[N:21])[CH:19]=[CH2:20]>O1CCCC1>[CH2:2]([O:4][C:5](=[O:10])[C:6]([CH2:20][CH2:19][C:18]#[N:21])=[C:7]([NH2:9])[NH2:8])[CH3:3]

참가 물질

5

반응물 3

HCID 7855AcrylonitrileHCID 8471TriethylamineHCID 124946853,3-Diamino-acrylic acid ethyl ester hydrochloride

생성물 1

HCID 124949064-Cyano-2-diaminomethylene-butyric acid ethyl ester수율 25%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

The resulting 3,3-diamino-acrylic acid ethyl ester hydrochloride (2.2 g, 13.2 mmol) was suspended in tetrahydrofuran (40 mL), triethylamine (2 mL, 14.3 mmol) and acrylonitrile (1.2 mL, 19.3 mmol) were added thereto, and the solution was refluxed for 6 hours. After the reaction was completed, the resulting triethylamine hydrochloride was filtered, and the filtrate was concentrated to obtain the title compound (0.6 g, 3.3 mmol, 25%).

후처리

  1. temperaturethe solution was refluxed for 6 hours
  2. filtrationthe resulting triethylamine hydrochloride was filtered
  3. concentrationthe filtrate was concentrated

출처 및 근거

ORD 기록
ord-c7c9ccec28754008a4a0fb919cbcca90
출처 데이터셋
uspto-grants-2011_04
특허 번호
US07932272B2

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