Methanol → 3-(Aminomethyl)biphenyl

HRID 2080040

반응식

HRID 2080040 반응식
[C:1]1([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)[CH:6]=[CH:5][CH:4]=[C:3]([C:7]#[N:8])[CH:2]=1.[H-].[Al+3].[Li+].[H-].[H-].[H-].CO.[Cl-].[NH4+]>O1CCCC1.O>[C:1]1([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)[CH:6]=[CH:5][CH:4]=[C:3]([CH2:7][NH2:8])[CH:2]=1

참가 물질

7

반응물 4

HCID 887MethanolHCID 25517Ammonium ChlorideHCID 34340[1,1'-Biphenyl]-3-carbonitrileHCID 21226445Aluminium lithium hydride

생성물 1

HCID 27603683-(Aminomethyl)biphenyl수율 63%

시약·촉매·용매 2

HCID 962Water용매HCID 8028Tetrahydrofuran용매2회

실험 절차

Next, a solution of the resulting biphenyl-3-carbonitrile (821 mg, 4.58 mmol) in tetrahydrofuran (5 mL) was added to a solution of lithium aluminum hydride (0.435 g, 11.5 mmol) in tetrahydrofuran (5 mL) that had been cooled on an ice bath, and the solution was stirred for 6 hours at room temperature. The reaction solution was cooled on an ice bath, a mixture solution of methanol and water (9:1) was added thereto, an aqueous solution of saturated ammonium chloride was further added, filtration was carried out through Celite pad and insoluble matter was removed. The filtrate was partitioned, the organic layer was dried over anhydrous magnesium sulfate, and the title compound (527 mg, 63%) was obtained as a brown oil. This was used in the next reaction without further purification.

후처리

  1. temperaturehad been cooled on an ice bath
  2. temperatureThe reaction solution was cooled on an ice bath
  3. filtrationfiltration
  4. customwas removed
  5. customThe filtrate was partitioned
  6. dry with materialthe organic layer was dried over anhydrous magnesium sulfate

출처 및 근거

ORD 기록
ord-b88dda3d777f4934bedbbbac1270a1ca
출처 데이터셋
uspto-grants-2011_04
특허 번호
US07932272B2

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