Water → HCID 23130682, 화합물

HRID 2080064노트

반응식

HRID 2080064 반응식
[H-].[Al+3].[Li+].[H-].[H-].[H-].[C:7]1([NH:13][CH2:14][C:15]2[CH:22]=[CH:21][C:18]([C:19]#[N:20])=[CH:17][CH:16]=2)[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1.O>O1CCCC1>[NH2:20][CH2:19][C:18]1[CH:21]=[CH:22][C:15]([CH2:14][NH:13][C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=2)=[CH:16][CH:17]=1

참가 물질

5

반응물 3

HCID 962WaterHCID 11148468Benzonitrile, 4-[(phenylamino)methyl]-HCID 21226445Aluminium lithium hydride

생성물 1

HCID 23130682HCID 23130682, 화합물수율 97.1%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매2회

실험 절차

Next, to a solution of lithium aluminum hydride (0.91 g, 24 mmol) in tetrahydrofuran (60 mL) was added a solution of the resulting 4-phenylaminomethyl-benzonitrile (2.0 g, 9.61 mmol) in tetrahydrofuran (5 mL), and the solution was stirred at room temperature for 2 hours. Water was added to the reaction solution, which was then extracted with ethyl acetate, dried over anhydrous magnesium sulfate, and the solvent was evaporated to obtain the title compound (1.98 g, 97%) as a yellow oil. This compound was used in the next reaction without purification.

후처리

  1. extractionwas then extracted with ethyl acetate
  2. dry with materialdried over anhydrous magnesium sulfate
  3. customthe solvent was evaporated

출처 및 근거

ORD 기록
ord-e91aeb5823c2405ead7cad30ca605678
출처 데이터셋
uspto-grants-2011_04
특허 번호
US07932272B2

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