Water → C-(5-(3-fluorophenoxy)thiophen-2-yl)methylamine

HRID 2080066노트

반응식

HRID 2080066 반응식
[F:1][C:2]1[CH:3]=[C:4]([CH:13]=[CH:14][CH:15]=1)[O:5][C:6]1[S:10][C:9]([C:11]#[N:12])=[CH:8][CH:7]=1.[H-].[Al+3].[Li+].[H-].[H-].[H-].O.C(OCC)(=O)C>O1CCCC1>[F:1][C:2]1[CH:3]=[C:4]([CH:13]=[CH:14][CH:15]=1)[O:5][C:6]1[S:10][C:9]([CH2:11][NH2:12])=[CH:8][CH:7]=1

참가 물질

6

반응물 4

HCID 962WaterHCID 8857Ethyl AcetateHCID 21226445Aluminium lithium hydrideHCID 231306135-(3-Fluorophenoxy)thiophene-2-carbonitrile

생성물 1

HCID 23130606C-(5-(3-fluorophenoxy)thiophen-2-yl)methylamine수율 80.7%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

To a solution of 5-(3-fluorophenoxy)thiophene-2-carbonitrile described in Preparation Example 22 (670 mg, 3 mmol) in tetrahydrofuran (30 mL) was added lithium aluminum hydride (460 mg, 12 mmol), and the solution was stirred at room temperature for 16 hours. Water and ethyl acetate were added to the reaction solution, which was then partitioned, the organic layer was filtered with NH silica gel, the filtrate was evaporated in vacuo, and the title compound (570 mg, 2.42 mmol, 80.7%) was obtained as a brown oil.

후처리

  1. customwas then partitioned
  2. filtrationthe organic layer was filtered with NH silica gel
  3. customthe filtrate was evaporated in vacuo

출처 및 근거

ORD 기록
ord-efebfa5e8509454b8eb7421c76feefbe
출처 데이터셋
uspto-grants-2011_04
특허 번호
US07932272B2

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