Water → 2-(5-Oxiranyl-furan-2-yl)-[1,3]dioxolane

HRID 2080111

반응식

HRID 2080111 반응식
[O:1]1[CH2:5][CH2:4][O:3][CH:2]1[C:6]1[O:10][C:9]([CH:11]=[O:12])=[CH:8][CH:7]=1.[Br-].[CH3:14][S+](C)C.[OH-].[K+].O>C(#N)C>[O:12]1[CH2:14][CH:11]1[C:9]1[O:10][C:6]([CH:2]2[O:3][CH2:4][CH2:5][O:1]2)=[CH:7][CH:8]=1

참가 물질

6

반응물 4

HCID 962WaterHCID 14797Potassium HydroxideHCID 2735154Sulfonium, trimethyl-, bromide (1:1)HCID 146165975-(1,3-Dioxolan-2-yl)furan-2-carbaldehyde

생성물 1

HCID 231307652-(5-Oxiranyl-furan-2-yl)-[1,3]dioxolane수율 102.1%

시약·촉매·용매 1

HCID 6342Acetonitrile용매

실험 절차

5-[1,3]Dioxolan-2-yl-furan-2-carbaldehyde (2.03 g, 12.1 mmol), trimethylsulfonium bromide (1.90 g, 12.1 mmol) and potassium hydroxide (779 mg, 13.9 mmol) were suspended in acetonitrile (75 mL), and the solution was stirred overnight at room temperature. Water was added to the reaction solution, which was then extracted with ethyl acetate, the organic layer was washed with brine and dried over anhydrous magnesium sulfate. The solvent was evaporated in vacuo, 2-(5-oxiranyl-furan-2-yl)-[1,3]dioxolane (2.25 g) was obtained as a pale yellow oil.

후처리

  1. extractionwas then extracted with ethyl acetate
  2. washthe organic layer was washed with brine
  3. dry with materialdried over anhydrous magnesium sulfate
  4. customThe solvent was evaporated in vacuo

출처 및 근거

ORD 기록
ord-f386fb9bc7834aaca3b002b00c2987de
출처 데이터셋
uspto-grants-2011_04
특허 번호
US07932272B2

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