Dimethylformamide → Methyl 2-[4-(ethylsulfonyl)phenoxy]-5-nitro-4-[(2-pyridinylcarbonyl)amino]benzoate

HRID 2080666노트

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HRID 2080666 반응식
C(=O)([O-])[O-].[K+].[K+].CN(C)C=O.F[C:13]1[CH:22]=[C:21]([NH:23][C:24]([C:26]2[CH:31]=[CH:30][CH:29]=[CH:28][N:27]=2)=[O:25])[C:20]([N+:32]([O-:34])=[O:33])=[CH:19][C:14]=1[C:15]([O:17][CH3:18])=[O:16].[CH2:35]([S:37]([C:40]1[CH:45]=[CH:44][C:43]([OH:46])=[CH:42][CH:41]=1)(=[O:39])=[O:38])[CH3:36]>O>[CH2:35]([S:37]([C:40]1[CH:45]=[CH:44][C:43]([O:46][C:13]2[CH:22]=[C:21]([NH:23][C:24]([C:26]3[CH:31]=[CH:30][CH:29]=[CH:28][N:27]=3)=[O:25])[C:20]([N+:32]([O-:34])=[O:33])=[CH:19][C:14]=2[C:15]([O:17][CH3:18])=[O:16])=[CH:42][CH:41]=1)(=[O:39])=[O:38])[CH3:36]

참가 물질

6

반응물 4

HCID 6228DimethylformamideHCID 11430Potassium CarbonateHCID 202362274-(Ethanesulfonyl)phenolHCID 57433540HCID 57433540, 화합물

생성물 1

HCID 57433541Methyl 2-[4-(ethylsulfonyl)phenoxy]-5-nitro-4-[(2-pyridinylcarbonyl)amino]benzoate수율 82.2%

시약·촉매·용매 1

HCID 962Water용매

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온도
80 °C

실험 절차

3.5 g of potassium carbonate was added to a dimethylformamide (110 ml) solution of 6 g of methyl 2-fluoro-5-nitro-4-[(2-pyridinylcarbonyl)amino]benzoate and 3.48 g of 4-(ethylsulfonyl)phenol obtained in Reference Example 2, and stirred under heat at 80° C. for 30 minutes. The reaction liquid was restored to room temperature, poured into 300 ml of water, and the formed solid was taken out through filtration. This was dried under reduced pressure to obtain 7.46 g of the entitled compound as a yellow solid.

후처리

  1. customobtained in Reference Example 2
  2. customThe reaction liquid
  3. customwas restored to room temperature
  4. filtrationthe formed solid was taken out through filtration
  5. customThis was dried under reduced pressure

출처 및 근거

ORD 기록
ord-e12567b778ec454bb495e6be41f75441
출처 데이터셋
uspto-grants-2011_04
특허 번호
US07932394B2

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