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Dimethylformamide → Methyl 5-[4-(ethylsulfonyl)phenoxy]-2-nitrobenzoate

HRID 2080668
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HRID 2080668 반응식
C(=O)([O-])[O-].[K+].[K+].CN(C)C=O.F[C:13]1[CH:14]=[CH:15][C:16]([N+:23]([O-:25])=[O:24])=[C:17]([CH:22]=1)[C:18]([O:20][CH3:21])=[O:19].[CH2:26]([S:28]([C:31]1[CH:36]=[CH:35][C:34]([OH:37])=[CH:33][CH:32]=1)(=[O:30])=[O:29])[CH3:27]>O>[CH2:26]([S:28]([C:31]1[CH:36]=[CH:35][C:34]([O:37][C:13]2[CH:14]=[CH:15][C:16]([N+:23]([O-:25])=[O:24])=[C:17]([CH:22]=2)[C:18]([O:20][CH3:21])=[O:19])=[CH:33][CH:32]=1)(=[O:30])=[O:29])[CH3:27]
참가 물질반응 조건실험 절차후처리출처 및 근거반응 노트

참가 물질

6

반응물 4

HCID 6228DimethylformamideHCID 11430Potassium CarbonateHCID 51520495-Fluoro-2-nitrobenzoic acid methyl esterHCID 202362274-(Ethanesulfonyl)phenol

생성물 1

HCID 57433573Methyl 5-[4-(ethylsulfonyl)phenoxy]-2-nitrobenzoate수율 100.3%

시약·촉매·용매 1

HCID 962
Water
용매

반응 조건

온도
80 °C

실험 절차

11 g of potassium carbonate was added to a dimethylformamide (150 ml) solution of 10.7 g of methyl 5-fluoro-2-nitrobenzoate and 11.1 g of 4-(ethylsulfonyl)phenol obtained from Reference Example 2, and stirred under heat at 80° C. for 90 minutes. The reaction liquid was restored to room temperature, then 300 ml of water was added to it, and the formed solid was taken out through filtration. This was dried under reduced pressure to obtain 19.7 g of the entitled compound as a creamy white solid.

후처리

  1. customThe reaction liquid
  2. customwas restored to room temperature
  3. filtrationthe formed solid was taken out through filtration
  4. customThis was dried under reduced pressure

출처 및 근거

ORD 기록
ord-01e8d790bb6d46edb016dc931f569a2d
출처 데이터셋
uspto-grants-2011_04
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US07932394B2

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