2-[2-(4-Dipropylaminobutyl)-1-methoxymethoxy-indan-5-ylmethyl]-isoindole-1,3-dione → 2-[2-(4-dipropylamino-butyl)-3H-inden-5-ylmethyl]-isoindol

HRID 2080739노트

반응식

HRID 2080739 반응식
[CH2:1]([N:4]([CH2:34][CH2:35][CH3:36])[CH2:5][CH2:6][CH2:7][CH2:8][CH:9]1[CH2:17][C:16]2[C:11](=[CH:12][CH:13]=[C:14]([CH2:18][N:19]3[C:27](=O)[C:26]4[C:21](=[CH:22][CH:23]=[CH:24][CH:25]=4)[C:20]3=O)[CH:15]=2)[CH:10]1OCOC)[CH2:2][CH3:3]>O1CCOCC1>[CH2:34]([N:4]([CH2:1][CH2:2][CH3:3])[CH2:5][CH2:6][CH2:7][CH2:8][C:9]1[CH2:17][C:16]2[C:11](=[CH:12][CH:13]=[C:14]([CH2:18][N:19]3[CH:27]=[C:26]4[C:21]([CH:22]=[CH:23][CH:24]=[CH:25]4)=[CH:20]3)[CH:15]=2)[CH:10]=1)[CH2:35][CH3:36]

참가 물질

3

반응물 1

HCID 231555482-[2-(4-Dipropylaminobutyl)-1-methoxymethoxy-indan-5-ylmethyl]-isoindole-1,3-dione

생성물 1

HCID 866149102-[2-(4-dipropylamino-butyl)-3H-inden-5-ylmethyl]-isoindol수율 107.5%

시약·촉매·용매 1

HCID 312751,4-Dioxane용매

실험 절차

The compound (113.0 mg) obtained in Example 11-11 was dissolved in dioxane (2.2 ml) and the whole was stirred at room temperature for 24 hours. The reaction solution was concentrated under reduced pressure. The residue was dissolved in chloroform and washed with a saturated aqueous sodium hydrogen carbonate solution and then with a saturated saline solution. The resultant was dried with anhydrous sodium sulfate and concentrated under reduced pressure. The residue was purified through silica gel column chromatography (chloroform/methanol), thereby obtaining the subject compound (98.8 mg) as a yellow oily substance.

후처리

  1. concentrationThe reaction solution was concentrated under reduced pressure
  2. dissolutionThe residue was dissolved in chloroform
  3. washwashed with a saturated aqueous sodium hydrogen carbonate solution
  4. dry with materialThe resultant was dried with anhydrous sodium sulfate
  5. concentrationconcentrated under reduced pressure
  6. customThe residue was purified through silica gel column chromatography (chloroform/methanol)

출처 및 근거

ORD 기록
ord-f679ddba13f148f0859a4e35168388f2
출처 데이터셋
uspto-grants-2011_04
특허 번호
US07932281B2

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