Dipropylamine → Methyl 4-dipropylaminomethylbenzoate

HRID 2080792

반응식

HRID 2080792 반응식
[CH3:1][O:2][C:3](=[O:12])[C:4]1[CH:9]=[CH:8][C:7]([CH2:10]Br)=[CH:6][CH:5]=1.[CH2:13]([NH:16][CH2:17][CH2:18][CH3:19])[CH2:14][CH3:15]>CN(C=O)C>[CH3:1][O:2][C:3](=[O:12])[C:4]1[CH:9]=[CH:8][C:7]([CH2:10][N:16]([CH2:17][CH2:18][CH3:19])[CH2:13][CH2:14][CH3:15])=[CH:6][CH:5]=1

참가 물질

4

반응물 2

HCID 8902DipropylamineHCID 256687Methyl 4-(bromomethyl)benzoate

생성물 1

HCID 23079192Methyl 4-dipropylaminomethylbenzoate

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

4-Bromomethylbenzoic acid methyl ester (831 mg) was dissolved in DMF (12.5 ml) and added with dipropylamine (971 μl) and the whole was stirred at room temperature for 2 hours. After completion of the reaction, the solvent was distilled off under reduced pressure. The residue was dissolved in chloroform, washed with a saturated aqueous sodium hydrogen carbonate solution, and subjected to extraction with chloroform. The organic layer was washed with a saturated saline solution and dried with anhydrous sodium sulfate. After filtration, the solvent was distilled off, thereby obtaining the subject compound (883 mg) as a brown solid.

후처리

  1. customAfter completion of the reaction
  2. distillationthe solvent was distilled off under reduced pressure
  3. dissolutionThe residue was dissolved in chloroform
  4. washwashed with a saturated aqueous sodium hydrogen carbonate solution
  5. extractionsubjected to extraction with chloroform
  6. washThe organic layer was washed with a saturated saline solution
  7. dry with materialdried with anhydrous sodium sulfate
  8. filtrationAfter filtration
  9. distillationthe solvent was distilled off

출처 및 근거

ORD 기록
ord-ecad13cdde93455eae55ba034193c3ee
출처 데이터셋
uspto-grants-2011_04
특허 번호
US07932281B2

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