Diethylamine → HCID 86614920, 화합물

HRID 2080894노트

반응식

HRID 2080894 반응식
[CH2:1]([O:3][C:4](=[O:35])[C@H:5]([NH:17]C(OCC1C2C=CC=CC=2C2C1=CC=CC=2)=O)[CH2:6][CH2:7][CH2:8][NH:9][C:10]([O:12][C:13]([CH3:16])([CH3:15])[CH3:14])=[O:11])[CH3:2].C(NCC)C>CN(C=O)C>[CH2:1]([O:3][C:4](=[O:35])[C@H:5]([NH2:17])[CH2:6][CH2:7][CH2:8][NH:9][C:10]([O:12][C:13]([CH3:15])([CH3:14])[CH3:16])=[O:11])[CH3:2]

참가 물질

4

반응물 2

HCID 8021DiethylamineHCID 67103783HCID 67103783, 화합물

생성물 1

HCID 86614920HCID 86614920, 화합물수율 114.1%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

The compound (1.9846 g) obtained in Example 96-1 was dissolved in DMF (19 ml) and added with diethylamine (14 ml) and the whole was stirred at room temperature for 30 minutes. After completion of the reaction, the solvent was distilled off. The residue was purified through silica gel column chromatography (chloroform/methanol), thereby obtaining the subject compound (1.2212 g) as a colorless oily substance.

후처리

  1. customAfter completion of the reaction
  2. distillationthe solvent was distilled off
  3. customThe residue was purified through silica gel column chromatography (chloroform/methanol)

출처 및 근거

ORD 기록
ord-ac75322babd2480d9dd16a284b29588a
출처 데이터셋
uspto-grants-2011_04
특허 번호
US07932281B2

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