Methanol → 4-(2-Bromophenoxy)-butyric acid methyl ester

HRID 2081313노트

반응식

HRID 2081313 반응식
[Br:1][C:2]1[CH:14]=[CH:13][CH:12]=[CH:11][C:3]=1[O:4][CH2:5][CH2:6][CH2:7][C:8]([OH:10])=[O:9].[CH3:15]O>>[CH3:15][O:9][C:8](=[O:10])[CH2:7][CH2:6][CH2:5][O:4][C:3]1[CH:11]=[CH:12][CH:13]=[CH:14][C:2]=1[Br:1]

참가 물질

3

반응물 2

HCID 887MethanolHCID 150701174-(2-Bromophenoxy)butanoic acid

생성물 1

HCID 150701264-(2-Bromophenoxy)-butyric acid methyl ester

실험 절차

A solution of 1.4 g of 4-(2-bromophenoxy)-butyric acid in 22 ml of methanol is mixed with 1 g of Amberlyst 15 and stirred for 5 hours at room temperature. Then, it is filtered from the Amberlyst 15, the filtrate concentrated by evaporation, the residue is taken up in diethyl ether, washed with dilute sodium carbonate solution, dried (Na2SO4) and concentrated by evaporation. 1.5 g of 4-(2-bromophenoxy)-butyric acid methyl ester is obtained as a colorless oil.

후처리

  1. filtrationThen, it is filtered from the Amberlyst 15
  2. concentrationthe filtrate concentrated by evaporation
  3. washwashed with dilute sodium carbonate solution
  4. dry with materialdried (Na2SO4)
  5. concentrationconcentrated by evaporation

출처 및 근거

ORD 기록
ord-72a4b8b5e6d044a1b9b7578c2b60f9bb
출처 데이터셋
uspto-grants-1993_02
특허 번호
US05183925

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