Hydrogen Peroxide → 2-Benzyl-1-oxo-1lambda~5~-pyridine
반응식
[CH2:1]([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][N:9]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[OH:14]O>C(O)(=O)C>[CH2:1]([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][N+:9]=1[O-:14])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1참가 물질
4
실험 절차
A solution of 2-benzylpyridine (10.0 g, 0.059 moles) and hydrogen peroxide (33% w/v, 4.02 g, 12.2 ml, 0.118 moles) in glacial acetic acid (40 ml) was heated at 60° C. for 17 hours. The reaction mixture was cooled to room temperature, the acetic acid evaporated under reduced pressure and the residue dissolved in chloroform. After neutralisation with potassium carbonate (20 g) the chloroform was removed to give 2-benzylpyridine-N-oxide (10.86 g, 99%) as a viscous oil which crystallised on standing.
후처리
- customthe acetic acid evaporated under reduced pressure
- dissolutionthe residue dissolved in chloroform
- customAfter neutralisation with potassium carbonate (20 g) the chloroform was removed
출처 및 근거
- ORD 기록
- ord-2fc156addcf546b79a1475884229092c
- 출처 데이터셋
- uspto-grants-1993_02
- 특허 번호
- US05185339
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