Hydrogen Peroxide → HCID 19780238, 화합물

HRID 2081586노트

반응식

HRID 2081586 반응식
[Cl:1][C:2]1[CH:14]=[CH:13][CH:12]=[CH:11][C:3]=1[CH2:4][C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][N:6]=1.[OH:15]O>C(O)(=O)C>[Cl:1][C:2]1[CH:14]=[CH:13][CH:12]=[CH:11][C:3]=1[CH2:4][C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][N+:6]=1[O-:15]

참가 물질

4

반응물 2

HCID 784Hydrogen PeroxideHCID 124351852-[(2-Chlorophenyl)methyl]pyridine

생성물 1

HCID 19780238HCID 19780238, 화합물수율 100%

시약·촉매·용매 1

HCID 176Acetic Acid용매

실험 절차

A solution of 2-(o-chlorobenzyl)pyridine (32 g, 0.16 moles) and hydrogen peroxide (30% w/v, 10.7 g, 36.0 ml, 0.31 moles) in glacial acetic acid (100 ml) was heated at 75° C. for 17 hours. The reaction mixture was cooled to room temperature, the acetic acid evaporated under reduced pressure and the residue dissolved in chloroform. After neutralisation with potassium carbonate (30 g) the chloroform was removed to give 2-(o-chlorobenzyl)pyridine-N-oxide (34.4 g, 100%) as a viscous oil.

후처리

  1. customthe acetic acid evaporated under reduced pressure
  2. dissolutionthe residue dissolved in chloroform
  3. customAfter neutralisation with potassium carbonate (30 g) the chloroform was removed

출처 및 근거

ORD 기록
ord-26b07bd79075432c8b440f9728a0dbde
출처 데이터셋
uspto-grants-1993_02
특허 번호
US05185339

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