3-[2-Butyl-3-(2-chloro-benzyl)-3H-imidazol-4-yl]-2-thiophen-2-ylmethyl-acrylic acid → (E)-3-[2-n-Butyl-1-{4-carboxyphenyl}-1H-imidazol-5-yl]-2-(2-thienyl)methyl-2-propenoic acid
반응식
C(C1N(C[C:13]2[CH:18]=[CH:17][C:16]([C:19]([O:21]CC)=[O:20])=[CH:15][C:14]=2Cl)C(C=O)=CN=1)CCC.C(C1C=CC(C2NC(C=O)=CN=2)=CC=1)(OCC)=O.[CH2:43]([C:47]1[N:48](CC2C=CC=CC=2Cl)[C:49](/[CH:52]=[C:53](\[CH2:57][C:58]2[S:59][CH:60]=[CH:61][CH:62]=2)/[C:54]([OH:56])=[O:55])=[CH:50][N:51]=1)[CH2:44][CH2:45][CH3:46]>>[CH2:43]([C:47]1[N:48]([C:13]2[CH:18]=[CH:17][C:16]([C:19]([OH:21])=[O:20])=[CH:15][CH:14]=2)[C:49](/[CH:52]=[C:53](\[CH2:57][C:58]2[S:59][CH:60]=[CH:61][CH:62]=2)/[C:54]([OH:56])=[O:55])=[CH:50][N:51]=1)[CH2:44][CH2:45][CH3:46]참가 물질
4
반응물 3
생성물 1
실험 절차
The title compound was prepared following the procedure of Example 42 replacing 2-n-butyl-1-[(4-carboethoxy-2-chlorophenyl)methy]imidazole-5-aldehyde with 2-n-butyl-[(4-carboethoxyphenyl]imidazole-5-aldehyde; mp 260°-265° C.(d).