Ammonia → 2-amino-3-nitro-N-methylaniline

HRID 2081900노트

반응식

HRID 2081900 반응식
[NH2:1][C:2]1[C:19]([N+:20]([O-:22])=[O:21])=[CH:18][CH:17]=[CH:16][C:3]=1[N:4]([CH3:15])S(C1C=CC(C)=CC=1)(=O)=O.S(=O)(=O)(O)O.N>O>[NH2:1][C:2]1[C:19]([N+:20]([O-:22])=[O:21])=[CH:18][CH:17]=[CH:16][C:3]=1[NH:4][CH3:15]

참가 물질

5

반응물 3

HCID 222AmmoniaHCID 1118Sulfuric AcidHCID 197788482-amino-3-nitro-N-methyl-N-tosylaniline

생성물 1

HCID 126202532-amino-3-nitro-N-methylaniline

시약·촉매·용매 1

HCID 962Water용매

반응 조건

온도
90 °C

실험 절차

0.0716 mol (23 g) of 2-amino-3-nitro-N-methyl-N-tosylaniline is added gradually, in the course of 10 minutes whilst stirring, to 230 ml of concentrated sulphuric acid to which 23 ml of water has been added and which has been heated to 90° C. beforehand. When the addition has ended, the reaction medium is kept at 90° C. for 5 minutes and then poured onto crushed ice. The acid aqueous solution obtained is rendered alkaline with the aid of ammonia solution in order to precipitate the expected product. The latter is filtered off, washed with water and recrystallised from 40 ml of alcohol. After drying in vacuo, it melts at 93° C.

후처리

  1. additionhas been added
  2. additionWhen the addition
  3. additionpoured
  4. customonto crushed ice
  5. customThe acid aqueous solution obtained
  6. customto precipitate the expected product
  7. filtrationThe latter is filtered off
  8. washwashed with water
  9. customrecrystallised from 40 ml of alcohol
  10. customAfter drying in vacuo, it melts at 93° C.

출처 및 근거

ORD 기록
ord-7c7874cb51a649b980ae2587f0e120b3
출처 데이터셋
uspto-grants-1993_02
특허 번호
US05186717

반응 노트

불러오는 중…