Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Benzyl Bromide → Boc-DTrp-OBzl
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Benzyl Bromide | HCID 7498 | — |
| 반응물 | Diisopropylethylamine | HCID 81531 | — |
| 반응물 | N-((tert-Butoxy)carbonyl)-D-tryptophan | HCID 111050 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | Boc-DTrp-OBzl | HCID 10739405 | 95% |
반응 단계
To an ice-cooled solution of Boc-D-Trp-OH (8.61 g) in DMF (100 ml) were added benzyl bromide (7.19 g) and diisopropylethylamine (4.02 g). The solution was stirred for two hours at the same temperature and overnight at room temperature. After evaporation, the residue was extracted with ethyl acetate. The organic layer was washed successively with water, sodium hydrogencarbonate solution, 0.5 hydrochlolic acid, and sodium chloride solution, and dried over magnesium sulfate. Evaporation gave Boc-D-Trp-OBzl (10.6 g) as a crystalline mass.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05187156 |
| 출처 데이터셋 | uspto-grants-1993_02 |
| ORD ID | ord-b08df90ed268472484e2250dbf5f4ea9 |
| 출처 메모 | uspto-grants-1993_02 |