Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Hydrochloric Acid → Boc-D-Trp(Tos)-OBzl
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Hydrochloric Acid | HCID 313 | — |
| 반응물 | 4-Toluenesulfonyl chloride | HCID 7397 | — |
| 반응물 | Sodium Hydroxide | HCID 14798 | — |
| 반응물 | Boc-DTrp-OBzl | HCID 10739405 | — |
| 촉매 | Ethanaminium, N,N,N-trimethyl-, chloride (1:1) | HCID 33992 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | Boc-D-Trp(Tos)-OBzl | HCID 131717761 | 116.1% |
반응 단계
Boc-D-Trp-OBzl (2.0 g) and ethyltrimethylammonium chloride (16.2 mg) were dissolved in methylene chloride (30 ml), and powdered sodium hydroxide (507 mg) was added. To this mixture was added a solution of Tos-Cl (1.45 g) in methylene chloride (5 ml) at room temperature. The reaction mixture was stirred for three and half an hour. After addition of 1N-hydrochloric acid (7.5 ml), the organic layer was separated, washed with sodium chloride solution, dried over magnesium sulfate, and evaporated to give Boc-D-Trp(Tos)-OBzl as an oil (3.23 g).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05187156 |
| 출처 데이터셋 | uspto-grants-1993_02 |
| ORD ID | ord-bca4c39040b84e01aa0e7df0d94e2915 |
| 출처 메모 | uspto-grants-1993_02 |