반응식
[CH:1]1[C:9](C(OC)=O)=[CH:8][CH:7]=[C:6]2[C:2]=1[CH:3]=[C:4]1[CH2:17][CH2:16][CH2:15][CH2:14][N:5]12.C1C=CC=C2C=1C=C1CCCCN12.[C:31](Cl)([Cl:33])=[O:32]>>[Cl:33][C:31]([C:1]1[CH:9]=[CH:8][CH:7]=[C:6]2[C:2]=1[CH:3]=[C:4]1[CH2:17][CH2:16][CH2:15][CH2:14][N:5]12)=[O:32]참가 물질
4
실험 절차
The methyl ester of Formula III wherein Z is --N(R2)-- and R1 and R2 are together --(CH2)3 --, namely methyl 6,7,8,9-tetrahydropyrido[1,2-a]indole-2-carboxylate, is prepared by reacting 6,7,8,9-tetrahydropyrido[1,2-a]indole with phosgene to form 1-chloroformyl-6,7,8,9-tetrahydropyrido[1,2-a]indole and subsequently converting this product to the methyl ester. A more detailed description of this procedure is set forth in Example 1 of this application. The 6,7,8,9-tetrahydropyrido[1,2-a]indole may be prepared via an intramolecular Wittig reaction (M. D. Crenshaw and H. Zimmer, J. Heterocyclic Chem., (1984) 21, 623).
출처 및 근거
- ORD 기록
- ord-003faa9db6db43e2af199169d5b84038
- 출처 데이터셋
- uspto-grants-1993_02
- 특허 번호
- US05189041
연결된 노트
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