Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Ethyl 1,2-dimethyl-1H-indole-3-carboxylate → (S)-1-[(1-azabicyclo[2.2.2]oct-3-yl)aminocarbonyl]-6,7,8,9-tetrahydropyrido[1,2-a]indole
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Ethyl 1,2-dimethyl-1H-indole-3-carboxylate | HCID 599139 | — |
| 반응물 | (S)-quinuclidin-3-amine | HCID 719216 | — |
| 반응물 | Methyl 6,7,8,9-tetrahydropyrido[1,2-a]indole-1-carboxylate | HCID 19778122 | — |
| 생성물 | (S)-1-[(1-azabicyclo[2.2.2]oct-3-yl)aminocarbonyl]-6,7,8,9-tetrahydropyrido[1,2-a]indole | HCID 53857764 | 82% |
반응 단계
Proceeding as in Example 2, Method B, but replacing (RS)-3-amino-1-azabicyclo[2.2.2]octane with (S)-3-amino-1-azabicyclo[2.2.2]octane and ethyl 1,2-dimethylindole-3-carboxylate with methyl 6,7,8,9-tetrahydropyrido[1,2-a]indole-1-carboxylate, from Example 1, there was prepared (S)-1-[(1-azabicyclo[2.2.2]oct-3-yl)aminocarbonyl]-6,7,8,9-tetrahydropyrido[1,2-a]indole (82% yield), m.p. 163°-164° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05189041 |
| 출처 데이터셋 | uspto-grants-1993_02 |
| ORD ID | ord-1934814f546f477287fd064d9dcbaca1 |
| 출처 메모 | uspto-grants-1993_02 |