N-(1-benzylpiperid-4-yl)-N-methylpropionamide → N-Methyl-N-(piperidin-4-yl)propionamide

HRID 2082345노트

반응식

HRID 2082345 반응식
C([N:8]1[CH2:13][CH2:12][CH:11]([N:14]([CH3:19])[C:15](=[O:18])[CH2:16][CH3:17])[CH2:10][CH2:9]1)C1C=CC=CC=1>C(O)C.[OH-].[Pd+2].[OH-]>[NH:8]1[CH2:13][CH2:12][CH:11]([N:14]([CH3:19])[C:15](=[O:18])[CH2:16][CH3:17])[CH2:10][CH2:9]1

참가 물질

4

반응물 1

HCID 19761195N-(1-benzylpiperid-4-yl)-N-methylpropionamide

생성물 1

HCID 19761222N-Methyl-N-(piperidin-4-yl)propionamide수율 60%

시약·촉매·용매 2

HCID 9942167Palladium hydroxide촉매HCID 702Ethanol용매

실험 절차

31 g of the amine obtained in Stage B are hydrogenated in 350 ml of ethanol with 1 g of palladium hydroxide at atmospheric pressure and room temperature. The mixture is filtered and evaporated to yield the desired product in the form of an oil.

후처리

  1. filtrationThe mixture is filtered
  2. customevaporated

출처 및 근거

ORD 기록
ord-0295d3c8d845438e84752f73a7d8dbc2
출처 데이터셋
uspto-grants-1993_02
특허 번호
US05189045

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