2-Fluoroaniline → 2-[(2-Fluorophenyl)amino]nicotinic acid

HRID 2082357노트

반응식

HRID 2082357 반응식
Cl[C:2]1[N:10]=[CH:9][CH:8]=[CH:7][C:3]=1[C:4]([OH:6])=[O:5].[F:11][C:12]1[CH:18]=[CH:17][CH:16]=[CH:15][C:13]=1[NH2:14]>C1(C)C(C)=CC=CC=1>[F:11][C:12]1[CH:18]=[CH:17][CH:16]=[CH:15][C:13]=1[NH:14][C:2]1[N:10]=[CH:9][CH:8]=[CH:7][C:3]=1[C:4]([OH:6])=[O:5]

참가 물질

4

반응물 2

HCID 95842-FluoroanilineHCID 762582-Chloronicotinic acid

생성물 1

HCID 23935552-[(2-Fluorophenyl)amino]nicotinic acid

시약·촉매·용매 1

HCID 7237O-Xylene용매

실험 절차

50 g of 2-chloronicotinic acid and 31 ml of 2-fluoroaniline in 180 ml of xylene are refluxed for 5 hours. The precipitate is filtered off and washed with xylene and then with water to yield the desired compound.

후처리

  1. filtrationThe precipitate is filtered off
  2. washwashed with xylene

출처 및 근거

ORD 기록
ord-798f6fe6fc054c2da83683a25000b2e4
출처 데이터셋
uspto-grants-1993_02
특허 번호
US05189045

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