Sulfuric Acid → (2-Methylbutyl)benzene

HRID 2082633노트

반응식

HRID 2082633 반응식
Br[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH3:8][CH:9]([CH2:22][CH3:23])[CH2:10]OS(C1C=CC(C)=CC=1)(=O)=O.S(=O)(=O)(O)O>CCOCC>[CH3:8][CH:9]([CH2:22][CH3:23])[CH2:10][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

참가 물질

5

반응물 3

HCID 1118Sulfuric AcidHCID 7961Bromobenzene2회HCID 3011991-Butanol, 2-methyl-, 1-(4-methylbenzenesulfonate)

생성물 1

HCID 107203(2-Methylbutyl)benzene수율 64.8%

시약·촉매·용매 1

HCID 3283Diethyl Ether용매2회

실험 절차

Phenylmagnesium bromide-ether solution was prepared from bromobenzene (64.5g, 0.41m), magnesium turnings (9.85g, 0.41m), and anhydrous ether (500ml). The reagent was cooled and (+)-β-methylbutyl-4-toluenesulfonate (200g, 0.82m) in ether (800ml) was added in drops. When the addition was complete, the reaction mixture was stirred for two hours, refluxed for two hours and left to stand overnight. Aqueous sulfuric acid was added until a clear solution was formed. The layers were separated. The aqueous layer was extracted with ether (3×250ml), and the combined organic layers were washed with sodium bicarbonate solution, water and dried over anhydrous sodium sulfate. The solvent was evaporated and the residue was steam-distilled. Fractional distillation of the crude product at reduced pressure yielded (+)-β-methylbutylbenzene (38.7g, 64.8%), bp. 74°-77° C at 12 mm pressure.

후처리

  1. temperatureThe reagent was cooled
  2. additionWhen the addition
  3. temperaturerefluxed for two hours
  4. waitleft
  5. waitto stand overnight
  6. customwas formed
  7. customThe layers were separated
  8. extractionThe aqueous layer was extracted with ether (3×250ml)
  9. washthe combined organic layers were washed with sodium bicarbonate solution, water
  10. dry with materialdried over anhydrous sodium sulfate
  11. customThe solvent was evaporated
  12. distillationthe residue was steam-distilled
  13. distillationFractional distillation of the crude product at reduced pressure

출처 및 근거

ORD 기록
ord-e6a52b362f0e44308be25e2d6078415c
출처 데이터셋
uspto-grants-1978_04
특허 번호
US04082428

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