3,3-Dimethyl-2,5-hexanedione → 5-Hydroxy-3,3-dimethylhexan-2-one

HRID 2082792노트

반응식

HRID 2082792 반응식
[CH3:1][C:2]([CH3:10])([CH2:6][C:7](=[O:9])[CH3:8])[C:3](=[O:5])[CH3:4].C1C2B3C(CCC2)CCCC3CC1.[Li]>O1CCCC1>[CH3:1][C:2]([CH3:10])([CH2:6][CH:7]([OH:9])[CH3:8])[C:3](=[O:5])[CH3:4]

참가 물질

4

반응물 2

HCID 1647423,3-Dimethyl-2,5-hexanedioneHCID 70418318Lithium perhydro-9b-boraphenalylhydride

생성물 1

HCID 203606715-Hydroxy-3,3-dimethylhexan-2-one수율 90%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

반응 조건

온도
0 °C

실험 절차

In a flask is placed 100 mmoles of 3,3-dimethyl-2,5-hexanedione in 50 ml. of tetrahydrofuran. The reaction mixture is cooled to 0° C. and 100 mmoles of lithium perhydro-9b-boraphenalylhydride is added slowly. A 90% yield of 3,3-dimethyl-5-hydroxy-2-hexanone is obtained.

후처리

  1. customIn a flask is placed

출처 및 근거

ORD 기록
ord-bb0063a3d7fa446099adeed3cdc06e61
출처 데이터셋
uspto-grants-1978_04
특허 번호
US04082810

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