Nitric Acid → HCID 20360787, 화합물

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[OH:1][C:2]1[CH:3]=[C:4]([CH:12]=[CH:13][CH:14]=1)[C:5]([CH2:7][CH2:8][C:9]([OH:11])=[O:10])=[O:6].[N+:15]([O-])([OH:17])=[O:16]>>[OH:1][C:2]1[CH:3]=[C:4]([CH:12]=[CH:13][C:14]=1[N+:15]([O-:17])=[O:16])[C:5]([CH2:7][CH2:8][C:9]([OH:11])=[O:10])=[O:6]

참가 물질

반응물 2

HCID 944Nitric Acid

HCID 2703964-(3-Hydroxyphenyl)-4-oxobutanoic acid

생성물 1

HCID 20360787HCID 20360787, 화합물

실험 절차

3-(3-Hydroxybenzoyl)propionic acid was added in portions to well stirred fuming nitric acid at -15° C. The resultant mixture was stirred a further 10 minutes in the cold then poured into ice-water. The crude product was triturated with methanol to give 3-(3-hydroxy-4-nitrobenzoyl)propionic acid, which after recrystallisation from water had m.p. 158° - 160.3° C (Found: C, 50.25; H, 3.75; N, 5.88; M+, 239 C10H9NO6 requires: C, 50.21; H, 3.79; N, 5.86%; M, 239)

후처리

customThe crude product was triturated with methanol

출처 및 근거

ORD 기록: ord-494e5732f498415ebdff14c956876c20
출처 데이터셋: uspto-grants-1978_04
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US04082843

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