Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Hydrochloric Acid → 5-(4-Chlorophenyl)pyrimidin-2(1H)-one
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Hydrochloric Acid | HCID 313 | — |
| 반응물 | Urea | HCID 1176 | — |
| 반응물 | Ammonium Chloride | HCID 25517 | — |
| 반응물 | 2-(4-Chlorophenyl)-3-(dimethylamino)acrylaldehyde | HCID 3448972 | — |
| 용매 | Ethanol | HCID 702 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | 5-(4-Chlorophenyl)pyrimidin-2(1H)-one | HCID 13605538 | 29.7% |
반응 단계
A mixture of 2-(4-chlorophenyl)dimethylaminopropenal (Example 145a) (5.13 g), urea (2.4 g), concentrated HCl (10 ml), water (4 ml) and ethanol (150 ml) was refluxed for 4 hours. After cooling to room temperature concentrated ammonium chloride was added until the pH was 7. The resulting yellow solid was filtered off and dried yielding 1.5 g of 5-(4-chlorophenyl)-2-pyrimidinone.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05728694 |
| 출처 데이터셋 | uspto-grants-1998_03 |
| ORD ID | ord-2f3265d28f2a442e9260aa23c827a764 |
| 출처 메모 | uspto-grants-1998_03 |