Ammonia → HCID 20359294, 화합물

HRID 2083173노트

반응식

HRID 2083173 반응식
[OH-].[NH4+].O.[CH3:4][N:5]([CH3:25])[CH2:6][CH2:7][C:8]1([C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=2)[CH2:18][C:17]2[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=2)[C:10](=[O:11])[O:9]1.N>[Zn].C(O)C>[CH3:25][N:5]([CH3:4])[CH2:6][CH2:7][CH:8]([C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1)[CH2:18][C:17]1[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=1[C:10]([OH:11])=[O:9]

참가 물질

7

반응물 4

HCID 222AmmoniaHCID 962WaterHCID 14923Ammonium HydroxideHCID 101085553-(2-Dimethylaminoethyl)-3,4-dihydro-3-phenylisocoumarin

생성물 1

HCID 20359294HCID 20359294, 화합물

시약·촉매·용매 2

HCID 23994Zinc촉매HCID 702Ethanol용매

실험 절차

To a well stirred suspension of 45 g. of zinc dust, 90 ml. of concentrated ammonium hydroxide, 45 ml. of water and 2 ml. of cupric sulfate maintained at 80° C. there is added 14.75 g. (0.05 mole) of 3-(2-dimethylaminoethyl)-3,4-dihydro-3-phenylisocoumarin in 50 ml. ethanol for about 30 minutes. The resulting mixture is heated at 85° C. for 30 hours while a slow stream of ammonia is passed through. The mixture is filtered while under heat and the solids washed throughly with 100 ml. of hot ammonium hydroxide. The combined filtrates are cooled and carefully acidified with concentrated hydrochloric acid to give 2-(β-[-2-dimethylaminoethyl]phenethyl)benzoic acid, m.p. 152° to 154° C.

후처리

  1. additionsuspension of 45 g
  2. additionthere is added 14.75 g
  3. filtrationThe mixture is filtered while
  4. temperatureunder heat
  5. washthe solids washed throughly with 100 ml
  6. temperatureThe combined filtrates are cooled

출처 및 근거

ORD 기록
ord-ef6b8b68f41b43c7bfc76cb2c5eba972
출처 데이터셋
uspto-grants-1978_04
특허 번호
US04083997

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